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Pistachios are a nutritious addition to your diet. They are made up of 20% protein, a much higher calorie-to-protein ratio than that of most nuts. This protein can make you feel full longer and help you manage your weight. Pistachios also boast a high amount of antioxidants, second only to walnuts and pecans. Eat more than the recommended handful, and you might actually start to gain weight. That's because nuts are calorie-dense, Jones says, meaning they contain more energy per ounce than many other foods.