Treating Chronic Rhinosinusitis - current SNOT transplant study

Dr. Amin Javer, MD, FRCSC, FARS, Otolaryngologist Treating Chronic Rhinosinusitis - current SNOT transplant study

Duration: 2 minutes 6 seconds

We decided on 40 patients with a transplant by itself and 40 patients with the placebo by itself and compare the results. To date, we have completed our first 40 patients, so that 20 have had a SNOT transplant and 20 have had a placebo. We are currently carrying out an interim analysis to see what the effect is of the study, if any. This is a well done study with two PhD students and several clinical research fellows over several years. It's a massive team that's been running the show. There are several surgeons involved and two PI's (Principal Investigators), one is a surgeon, that's myself, and a PhD scientist Amee Manges from the lab at UBC. The team is very dedicated to doing this in the best possible manner with all the checks and balances in place. We have received a CIHR grant for over half a million dollars to do this study properly. It is a double-blind placebo-controlled study, which means that the investigators and the patients do not know what they have received. This is the largest double blinded placebo-controlled trial done anywhere for SNOT transplants, and this is the first time that this has been done in so much detail, for example, we are looking at the metagenomics of the bacteria ie. we are identifying in detail the bacteria present in the sick sinuses, in the donor mucus and in the recipient patients over a period of 6 months to see if the bacteria change over time. We will be the first centre in the world to publish such detailed data.

Presenter: Dr. Amin Javer, Otolaryngologist, Vancouver, BC

Local Practitioners: Otolaryngologist